Tottenham vs Manchester United: Spurs will welcome back a raft of first-team regulars, having made eight changes for the FA Cup win at Tranmere.
Eric Dier is still out following appendix surgery and Lucas Moura is an injury doubt, but Mousa Dembele and Jan Vertonghen are back in training.
Paul Pogba is set to be available for Manchester United after he missed the FA Cup third round with a leg problem.
Eric Bailly remains suspended, while Chris Smalling could miss a seventh straight game because of a foot injury.
Marcos Rojo has returned to Argentina to continue his rehabilitation.
- Spurs could win three consecutive top-flight meetings with Manchester United for the first time since 1960.
- United have lost their last three Premier League matches at Spurs, having been defeated just three times in the previous 23 games (W12, D8).
- The two sides have scored 40 goals between them in their last six matches in all competitions.
- Tottenham have lost just once in 11 matches in all competitions, winning nine and drawing one.
- They could reach 51 points in this match, which would be at least two games quicker than in any other Premier League season.
- Spurs could lose consecutive Premier League home fixtures for the first time since May 2015.
- They have lost four of their eight Premier League matches at Wembley Stadium against top-six teams.
- Tottenham are on a club record run of 25 consecutive league matches without a draw (W19, L6) since a 1-1 stalemate at Brighton on 17 April.
- Harry Kane could score in seven consecutive matches for the first time.
- Christian Eriksen has scored an unrivalled 19 Premier League goals from outside the penalty area since his debut in September 2013.
- Manchester United have won four consecutive Premier League games for the first time since April.
- They are the only club with a 100% Premier League record since Ole Gunnar Solskjær replaced Jose Mourinho.
- The Red Devils are winless in five matches against established top-six opposition this season, drawing twice and losing three times.
- United could keep consecutive clean sheets in the Premier League for the first time this season.
- Since Mourinho was sacked, Paul Pogba has scored four goals and set up three. Only Tottenham’s Son Heung-Min, with five goals and three assists, has been involved in more goals during that period.
- Marcus Rashford has been directly involved in nine goals in his last eight Premier League games, scoring four and assisting five.
- Spurs are looking to win three consecutive top-flight meetings with Manchester United for the first time since September 1960.
- Manchester United have lost their last three away Premier League matches against Spurs – they had lost just three of their first 23 against them in the competition between 1992 and 2014 (W12 D8).
- Spurs could become the first team since Everton in 1987 to win four consecutive home top-flight matches against Manchester United.
- Manchester United have lost two of their last three matches at Wembley in all competitions (including this exact fixture last season), as many as they had in their last 15 at the ground (W8 D5 L2).
- Manchester United have won just four of their last 17 away Premier League matches in London (D4 L9).
- Tottenham haven’t lost consecutive home league games since May 2015, when they lost against Aston Villa and Man City.
- After winning their last four league games against fellow ‘big six’ opposition last season, Manchester United are winless in their five such matches this term (D2 L3).
- Victory here would see Ole Gunnar Solskjaer equal Matt Busby’s record of a Manchester United manager winning their first five league games in charge of the club.
- Harry Kane and Lucas Moura (2) were on the scoresheet in Tottenham’s 3-0 win in the reverse fixture – only Clint Dempsey in 2012/13 and Jermaine Jenas in 2005/06 have scored home and away against Man Utd for Spurs in the same Premier League campaign.